Which agent is a nonsedating antihistamine best international dating service
receptor antagonists) are commonly found in over-the-counter and prescription medications used for motion sickness, control of allergy-related itching, and cough and cold palliation and used as sleep aids (Table II–9).Acute intoxication with antihistamines results in symptoms very similar to those of anticholinergic poisoning.This adverse effect is linked to their effect on potassium channels leading to slowing of repolarization rate.H1-antihistamines without sedating effect currently marketed are mequitazine, cetirizine, loratadine, mizolastine, fexofenadine because they do not cross blood-brain and thus their effects remain peripheral.
They have a longer duration of action and longer plasma half-life than the first generationdrugs, which makes it possible to reduce the number of daily intakes.
They do not have, in normal dose, antimuscarinic effect, except mequitazine which has a mild antimuscarinic effect.
It was brought to market by Hoechst Marion Roussel (now Sanofi-Aventis) and was marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia.
It was superseded by fexofenadine in the 1990s due to the risk of a particular type of disruption of the electrical rhythms of the heart (specifically cardiac arrhythmia caused by QT interval prolongation) and has been withdrawn from markets worldwide. It is a prodrug, generally completely metabolized to the active form fexofenadine in the liver by the enzyme cytochrome P450 3A4.